North Carolina ( (listen)) is a state in the Southeastern region of the United States. North Carolina is the 28th largest and 9th-most populous of the 50 United States. It is bordered by Virginia to the north, the Atlantic Ocean to the east, Georgia and South Carolina to the south, and Tennessee to the west. Raleigh is the state's capital and Charlotte is its largest city. The Charlotte metropolitan area, with an estimated population of 2,569,213 in 2018, is the most-populous metropolitan area in North Carolina, the 23rd-most populous in the United States, and the largest banking center in the nation after New York City. The Raleigh-Durham-Cary combined statistical area is the second-largest metropolitan area in the state, with an estimated population of 2,079,687 in 2019, and is home to the largest research park in the United States, Research Triangle Park. Earliest discoveries of human occupation in North Carolina date back to 10,000 years ago, found at the Hardaway Site. North Carolina was inhabited by Carolina Algonquian, Iroquoian, and Siouan speaking tribes of Native Americans prior to the arrival of Europeans. North Carolina was established as a royal colony in 1729 and was one of the Thirteen Colonies. North Carolina is named in honor of King Charles I of England who first formed the English colony, Carolus being Latin for "Charles". The Halifax Resolves resolution adopted by North Carolina on April 12, 1776, was the first formal call for independence from Great Britain among the American Colonies during the American Revolution.On November 21, 1789, North Carolina became the 12th state to ratify the United States constitution. In the run-up to the American Civil War, North Carolina declared its secession from the Union on May 20, 1861, becoming the tenth of eleven states to join the Confederate States of America. Following the Civil War, the state was restored to the Union on July 4, 1868. On December 17, 1903, Orville and Wilbur Wright successfully piloted the world's first controlled, sustained flight of a powered, heavier-than-air aircraft at Kitty Hawk in North Carolina's Outer Banks. North Carolina uses the slogan "First in Flight" on state license plates to commemorate this achievement, alongside a newer alternative design bearing the slogan "First in Freedom" in reference to the Mecklenburg Declaration and Halifax Resolves. North Carolina is defined by a wide range of elevations and landscapes. From west to east, North Carolina's elevation descends from the Appalachian Mountains to the Piedmont and Atlantic coastal plain. North Carolina's Mount Mitchell at 6,684 feet (2,037 m) is the highest point in North America east of the Mississippi River. Most of the state falls in the humid subtropical climate zone; however, the western, mountainous part of the state has a subtropical highland climate.